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Meet Alpha-Lipoic Acid, Your New Go-To Antioxidant Ingredient

  • A natural antioxidant found in the body
  • Soluble in both water and oil
  • Gentle enough for sensitive skin
  • Has anti-aging and soothing benefits
  • It has great skin penetration
  • Delays fine lines and wrinkles apparition
  • Promotes collagen synthesis

Whether it’s a rich serum or luxurious cream, there are endless antioxidant-rich products vying for your attention. From vitamin C to resveratrol to niacinamide, the actives make the difference, and there are plenty to choose from, but recently, you may have noticed another one fighting for shelf space. Case in point: alpha-lipoic acid. While the name might sound intimidating, alpha-lipoic acid serves as a potent dose of protection, exerts soothing effects, and provides anti-aging benefits. So, whether you’re a stranger to this compound or want to add it to your routine and need to know whether that’s a good idea, here is all you need to know about the benefits of alpha-lipoic acid for skin.

What is alpha-lipoic acid?

Alpha-lipoic acid (or thioctic acid or lipoic acid) is an antioxidant naturally found in every cell of the body, where it helps convert glucose into energy.[1] Its main role in skincare is to neutralize free radicals and defend the skin against oxidative stress, the number one culprit for premature aging signs. But really, alpha-lipoic acid can improve the skin on multiple fronts.

Alpha-lipoic acid benefits for skin

  • Exerts antioxidant activity: The major benefit of alpha-lipoic acid for skin is due to its antioxidant activity, meaning it donates an electron to unstable molecules from free radicals to protect the skin against oxidative damage. Additionally, evidence suggests that alpha-lipoic acid may help regenerate other antioxidants in the skin, such as coenzyme Q10 and vitamin C and make them active again.[2]
  • Increases glutathione levels: By increasing glutathione (a natural antioxidant in the body), alpha-lipoic acid consolidates the skin’s antioxidant defense and protects cells from oxidative stress.[1][3]
  • Induces collagen production: In addition to protecting collagen due to its antioxidant activity, alpha-lipoic acid stimulates fibroblasts to produce more collagen and keratin, resulting in resilient skin and less noticeable fine lines.[4][5]
  • Improves UV-induced pigmentation: Alpha-lipoic acid also acts as an exfoliant to encourage the skin to shed off dead cells, which in turn smoothes texture and makes dark spots caused by the sun fade over time.[6]
  • Reverses photo-damaged skin: Applying a cream with 5% alpha-lipoic acid was found to visibly improve photoaged skin in 12 weeks.[7]

Side effects

Alpha-lipoic acid is considered a safe and gentle compound for all skin types, including sensitive ones. However, as it’s the case with any new skincare product, it’s wise to perform a patch test before going all in.

How to use 

To benefit from the antioxidant and collagen-boosting effects of alpha-lipoic acid you can use skincare products that contain it or take supplements. There’s enough research on both topical and oral use of alpha-lipoic acid, all showing promising benefits for the skin. 

For topical application, alpha-lipoic acid works best in serums because it allows better skin penetration than other formulations. It’s also a versatile ingredient that pairs nicely with most skincare actives, including retinol, AHAs, and BHAs, and especially with other antioxidants like vitamin C and glutathione, so it should be relatively easy to integrate into your routine. 

Alpha-lipoic acid products

More than a few products have this nifty ingredient in their formula. From serums to moisturizers, sunscreens, and foundations, here are the best alpha-lipoic acid products coveted by those in the know.


Perricone MD High Potency Classics Face Firming Serum

With a meaningful concentration of alpha-lipoic acid, plus glycolic acid (exfoliant), sodium hyaluronate (hydrator), and DMAE (skin tightener), this serum does everything from firming to reducing wrinkles and sagging and strengthening the antioxidant defense. It’s a bit pricier, but it’s worth every penny — reviewers attest to it.

Perricone MD High Potency Classics Face Firming Serum


Derma E Ultra Lift Firming DMAE Moisturizer

This moisturizer packs a bunch of anti-agers, including DMAE, retinol, and an oil-soluble form of vitamin C, along with antioxidants and humectants to hydrate, lift, firm, and smooth the skin. It’s cruelty-free, vegan, and skips alcohol.

Derma E Firming Dmae Moisturizer Alpha Lipoic Acid & C-Ester


Boscia Plant Stem Cell And Ceramide Barrier-Defense Moisturizer

While shea and mango butters veil the skin in a cocoon of rich moisture, ceramide and cholesterol increase moisture retention, and alpha lipoic acid and melon extract provide antioxidant defense. The light yet rich texture comforts the skin instantly and leaves it visibly hydrated.

Boscia Plant Stem Cell And Ceramide Barrier-Defense Moisturizer


EltaMD UV Physical Broad-Spectrum SPF 41 Sunscreen

This mineral sunscreen not only provides high UVA and UVB protection with zinc oxide and titanium dioxide but also contains three powerful antioxidants (linoleic acid, quercetin, and thioctic acid) to maximize the skin’s defense against free radicals and other external aggressors. Whether your skin is dry, sensitive, or oily, EltaMD UV Physical Sunscreen will fit your complexion like a glove.

EltaMD UV Physical Broad-Spectrum SPF 41 Sunscreen


Paula’s Choice Resist Super Antioxidant Serum

In addition to thioctic acid, this serum loads vitamins C and E, coenzyme Q10, superoxide dismutase EGCG, and glutathione for a serious dose of antioxidant protection. There’s also ceramide and peptide to reinforce the skin, all in a lightweight formula that penetrates easily without leaving the skin tacky or sticky.

Paula's Choice Resist Super Antioxidant Serum


Women’s Concepts uses reliable sources, including dermatologists’ insights, clinical trials, and scientific journals, to find accurate information and support all the facts shared in our articles. All statements and claims have clear and legit references. Read our editorial policy to learn more about our sources of information, our process of researching and fact-checking the content, and how our team strives to keep all articles updated, completed, and trustworthy.

    1. Oregon State University, Micronutrient Information Center, Lipoic Acid
    2. Salehi B, Berkay Yılmaz Y, Antika G, Boyunegmez Tumer T, Fawzi Mahomoodally M, Lobine D, Akram M, Riaz M, Capanoglu E, Sharopov F, Martins N, Cho WC, Sharifi-Rad J. Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules. 2019 Aug 9;9(8):356. doi: 10.3390/biom9080356. PMID: 31405030; PMCID: PMC6723188.
    3. Nguyen H, Gupta V. Alpha-Lipoic Acid. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan.
    4. Tsuji-Naito K, Ishikura S, Akagawa M, Saeki H. α-Lipoic acid induces collagen biosynthesis involving prolyl hydroxylase expression via activation of TGF-β-Smad signaling in human dermal fibroblasts. Connect Tissue Res. 2010 Oct;51(5):378-87. doi: 10.3109/03008200903486188. PMID: 20604712.
    5. Kim K, Kim J, Kim H, Sung GY. Effect of α-Lipoic Acid on the Development of Human Skin Equivalents Using a Pumpless Skin-on-a-Chip Model. Int J Mol Sci. 2021 Feb 22;22(4):2160. doi: 10.3390/ijms22042160. PMID: 33671528; PMCID: PMC7927099.
    6. Kubota Y, Musashi M, Nagasawa T, Shimura N, Igarashi R, Yamaguchi Y. Novel nanocapsule of α-lipoic acid reveals pigmentation improvement: α-Lipoic acid stimulates the proliferation and differentiation of keratinocyte in murine skin by topical application. Exp Dermatol. 2019 Feb;28 Suppl 1:55-63. doi: 10.1111/exd.13828. PMID: 30698882.
    7. Beitner H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. Br J Dermatol. 2003 Oct;149(4):841-9. doi: 10.1046/j.1365-2133.2003.05597.x. PMID: 14616378.
Who wrote this?
Picture of Ana Vasilescu
Ana Vasilescu
Ana Vasilescu is the founder of Women's Concepts and a certified skincare consultant. She has over five years of experience working in the beauty editorial industry and over a decade as an acne sufferer. With a background in dermatological research, Ana brings a wealth of expertise to a diverse range of topics, from buzzy ingredients to anti-aging and acne advice. She holds a BA in Sociology and Political Sciences. Find her on LinkedIn or Instagram.
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