Superoxide Dismutase in Skincare Explained: The Most Powerful Antioxidant Of All

The full 101 on superoxide dismutase for skin.

We’re all fond of antioxidants as they’re our most trusty allies in battling external foes from depleting skin integrity. And I know when I say antioxidants, you probably think of vitamin C or resveratrol, but these aren’t the only powerhouses you should be focused on. That’s why in today’s post, we’ll introduce you to the big league of antioxidants, the strongest of all, yet very few are familiar with it: meet superoxide dismutase in skincare. Maybe it isn’t as popular as its counterparts, but this superpower antioxidant shouldn’t fall by the wayside and could very likely be your ticket to unbreakable skin. So read on to find out everything you need to know about superoxide dismutase for skin.

What is superoxide dismutase?

Superoxide dismutase (SOD) is the body’s most powerful antioxidant enzyme found in all our cells that form the front line of defense against highly reactive radicals. What superoxide dismutase does for skin is hunt and break down these cell-damaging molecules, which in turn prevents all sorts of issues such as premature aging and oxidative stress.[1]

Now, the thing that makes SOD stand above other antioxidants is that it continues to fight the harmful radicals even after the neutralization process, compared to others like vitamin C or E, which only work during the process. That means SOD keeps your skin protected all day long, 24/7, even when you haven’t supplemented your body with it for weeks. However, that only happens if you have enough superoxide dismutase in your cells, which is difficult to maintain since the natural SOD levels drop as we age.[2] Hence, to keep skin shielded from oxidative damage, you have to complement SOD levels either by eating foods rich in superoxide dismutase, applying topical products, or taking supplements.

As a side note, SOD is actually found in all kingdoms of life, including in vegetables and green plants, which are excellent sources to get your intake of superoxide dismutase.

What does it do to your skin?

Superoxide dismutase is used in skincare mostly as an anti-aging and restorative ingredient due to its antioxidant and free radical-scavenging power. There’s also evidence suggesting superoxide dismutase possesses anti-inflammatory properties, making it a great multitasker that can give you a healthy and resilient complexion.[3] More exciting still, emerging research shows that superoxide dismutase can prevent skin aging by promoting collagen production and reducing protein degradation, helping preserve skin firmness and thickness.[4] P.S: More collagen is needed not only for anti-aging but also for wound healing, so superoxide dismutase is truly a skin savior for all of us.

Given the above, the skin benefits of superoxide dismutase include:

  • Offsets oxidative stress
  • Supports wound healing
  • Boosts collagen
  • Prevents aging signs such as wrinkles and fine lines
  • Reduces UV-induced damage
  • Softens scars

Is it safe?

Since the body produces it, superoxide dismutase is considered safe for skin whether topically applied or taken orally. However, if you’re pregnant or breastfeeding, you should avoid superoxide dismutase to stay safe, as there is not enough solid evidence to confirm how it reacts in these cases.

How to use superoxide dismutase

Your body makes superoxide dismutase naturally, but you can boost its levels for more intense benefits by eating fresh food sources of SOD (like broccoli and cabbage), taking supplements, or using skincare products containing SOD. However, there are a few downsides to the topical use of superoxide dismutase for skin. That is, the ingredient is very unstable and has a high molecular weight, affecting its delivery into the skin. Hence, the most effective way to use superoxide dismutase for skin is to take it internally from your diet or supplements. Last but not least, you should still use skincare products infused with superoxide dismutase to reap all the benefits. We consider the following products to be the best:

Take takeaway

Superoxide dismutase remains one of the most important antioxidant defenses against free radicals in the body. So you should include it in your skincare routine ASAP to keep your skin healthy, especially since its levels start to decline with age. If you’re a skincare enthusiast, our skincare dictionary is a great place to keep an eye on all ingredients and learn how you can mix them to max out your beauty routine.


  1. Younus H. Therapeutic potentials of superoxide dismutaseInt J Health Sci (Qassim). 2018;12(3):88-93.
  2. Inal ME, Kanbak G, Sunal E. Antioxidant enzyme activities and malondialdehyde levels related to aging. Clin Chim Acta. 2001 Mar;305(1-2):75-80. doi: 10.1016/s0009-8981(00)00422-8. PMID: 11249925.
  3. Artur Shariev, Spiro Menounos, Alistair J. Laos. Skin protective and regenerative effects of RM191A, a novel superoxide dismutase mimetic. Redox Biology.
  4. Lee MJ, Agrahari G, Kim HY, An EJ, Chun KH, Kang H, Kim YS, Bang CW, Tak LJ, Kim TY. Extracellular Superoxide Dismutase Prevents Skin Aging by Promoting Collagen Production through the Activation of AMPK and Nrf2/HO-1 Cascades. J Invest Dermatol. 2021 Oct;141(10):2344-2353.e7. doi: 10.1016/j.jid.2021.02.757. Epub 2021 Apr 6.
Who wrote this?
Ana Vasilescu
Ana Vasilescu
Ana Vasilescu is the founder of Women's Concepts and a certified skincare consultant. She has over five years of experience working in the beauty editorial industry and over a decade as an acne sufferer. With a background in dermatological research, Ana brings a wealth of expertise to a diverse range of topics, from buzzy ingredients to anti-aging and acne advice. She holds a BA in Sociology and Political Sciences. Find her on LinkedIn or Instagram.
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