Fighting Skin Aging? This PolyPeptide Firming Serum Will Blow Your Expectations

Own Courtesy
We may include products - handpicked by our editors - we find useful for our readers. When you buy through our retail links, we may earn an affiliate commission — view our product review process and sources of information.

I know there’s no shortage of products that vow to transform skin. And I know that few actually deliver. Clinical Skin PolyPeptide Serum is one of them.

If I had to rank my top skincare concerns from most to least burning, I’d say uneven texture number one, followed by dullness and large pores. So when I was offered to test Clinical Skin PolyPeptide Firming Serum — a dermatologist-favorite elixir that promises to reduce fine lines look, plump, firm, and improve texture — I happily jumped at the chance.

About my skin: untextured and dull

For context, my skin has been on a journey throughout the years. Hormonal imbalances as a teen resulted in acne, hence ice box scars (yes, I was squeezing pimples) and, consequently, rough texture and large pores. And textured skin is less able to reflect light, which is why my complexion appears dull and lackluster than luminous and glowy. 

The formula: peptides for the win

As the name suggests, Clinical Skin PolyPeptide Firming Serum focuses on peptides, the little messengers that trigger cells to perform specific actions, such as inducing collagen and elastin production. Here’s a bit about what each of these peptides does: 

  • Acetyl Hexapeptide-8: which also goes by Argireline, is called the “botox in a jar” peptide due to its ability to increase moisture and decrease wrinkles.[1]
  • Bis(Tripeptide-1) Copper Acetate: aka copper peptide, is a mix of copper and amino acids that regenerate skin, spur collagen growth, enhance firmness and diminish UV-induced damage.[2]
  • Palmitoyl Tripeptide-28: a key compound that helps build skin proteins, while protecting the existing collagen from degradation.[3]
  • Palmitoyl Tripeptide-38: also known as Matrixyl, helps build proteins found in the skin matrix (collagen and hyaluronic acid).[4]

Additionally, the serum boasts a blend of ceramidescholesterol, and sodium hyaluronate that promote firmness and elasticity and reinforce the protective barrier. Plus, it has ascorbic acid (the pure form of vitamin C) and glutathione, both known for their antioxidant, brightening, and collagen-boosting abilities.[5]

P.S.: I love that the formula is void of fragrance, alcohol, mineral oil, and parabens and is cruelty-free.

What it does

When you pay for Clinical Skin PolyPeptide Firming Serum, you pay for results. This serum does literally anything from banishing dullness and minimizing wrinkles look to protecting, hydrating, and brightening the skin. It’s a true multi-tasker that can fight most skincare concerns out there.

The feel: rich and incredibly absorbent

Everything about this serum is rich. The white liquid is dense, yet it doesn’t feel heavy, oily, or watery. It spreads easily over the skin and absorbs instantly without leaving any tacky or sticky feeling, and it beautifully sits under moisturizer.

clinical skin polypeptide serum application

The results: I’m impressed

And further addicted. My skin (normally prone to dullness) appears luminous and supple, hydrated, and the glow it gives me is unbeatable. The little lines are less noticeable, the pores appear refined, and it never gave me any reaction. After using this miracle serum once a day (you can apply it AM and PM, but I’ve just been doing nights) for almost two months, my skin has changed. This makes total sense since the serum is jam-packed with actives that aid in building proteins, humectants, minerals, and vitamins.

The value: pricey but justified

Not everyone is willing to drop $250 on a serum, but peptides are usually expensive to formulate, and this serum loads a serious amount of them. On the bright side, the serum has 50ml, and a little goes a long way, so it lasts a long time. Plus, with each purchase of PolyPeptide Firming Serum, you get a Pétrissage Massage Beauty Roller (valued at $75), a great roller that massages the skin emulating the grip of a petrissage massage, increasing product absorption and boosting blood flow for enhanced benefits.

Clinical Skin PolyPeptide Firming Serum

Where to buy Clinical Skin PolyPeptide Firming Serum

The verdict

I endorse this serum because it delivers every single time. Sure, peptides are the main selling pitch in a lot of products out there, but considering this contains a generous amount of them, it’s good to know the higher price point equates to a very concentrated product. Five drops every evening, and it did hydrate my skin, leaving it plump, soft, luminous, and with an evener texture. Lastly, one thing I know: I don’t want to be without it.


  1. Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Am J Clin Dermatol. 2013 Apr,
  2. Safety Assessment of Tripeptide-1, Hexapeptide-12, their Metal Salts and Fatty Acyl Derivatives, and Palmitoyl Tetrapeptide-7 as Used in Cosmetics, June 9-10, 2014,
  3. Creative Peptides, Palmitoyl-tripeptide-28,
  4. Topical Peptide Treatments with Effective Anti-Aging Results, Source
  5. Aldag C, Nogueira Teixeira D, Leventhal PS. Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature. Clin Cosmet Investig Dermatol. 2016 Nov.
Who wrote this?
Ana Vasilescu
Ana Vasilescu
Ana is a sociologist and feminist with a shared passion for literature, psychology, and skincare, the combo that made her determined to start Women's Concepts. With over five years of experience in dermatological research, she has now become a certified skincare consultant keen to convince others of the importance of a diligent routine. Her close relationships with dermatologists around the globe, along with years of researching, analyzing studies, and hand-testing products on a daily basis, made Ana one of the best persons you can get advice from.
Subscribe to our newsletter
Subscribe to our newsletter to get access to exclusive content, offers, and products.
Was this article helpful?
Awesome! Would you like to share it?
That's too bad. Thank you for your feedback!
Why trust us?
Women's Concepts relies on the latest scientific research to provide accurate, complete, and fact-based information in skincare, on which we're willing to stake our reputation. Our team includes skincare experts who are highly regarded in their fields and committed to upholding the best standards of research. We spend quality time vetting every single product we recommend and double-checking all the facts shared on Women's Concepts. We always stand on the side of inclusivity, and our mission is to help everyone fix their skin issues as they arise and leverage the products they buy to achieve their goals. You can view our expert review board and everything about our editorial guidelines here.
Women's Concepts Logo
Join Us