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11 Best Copper Peptide Serums That Promote Firmer, More Elastic Skin

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My latest skincare obsession? Multitasking ingredients. And the standout star that is now never missing from my routine? Yes, you’re right, copper peptides. After researching this ingredient, I decided to save you some time and list the best serums with copper peptides. The good news is that everyone can add them to their beauty arsenal to promote firmer and more elastic skin.

What are copper peptides?

Copper peptides are created by mixing copper with three amino acids (glycyl-histidyl-lysine), and you can find it under the name GHK-Cu in skincare products.[1] Copper might ring a bell as that shiny, reddish metal, but it’s also an essential mineral in our bodies. It has a key role in creating red blood cells and maintaining a strong immune system. On the other hand, peptides are chains of amino acids that act like building blocks of proteins (think collagen and elastin). These proteins are like the scaffolding of your skin, giving it texture, strength, and elasticity we all love.

Why should you use copper peptides?

First, a copper peptide serum can rebuild collagen and elastin levels. These are the key proteins to give your skin firmness and elasticity. Because copper peptides work under the outer layers of the skin, they can stimulate the cells that produce collagen. In fact, in a study of 40 women between 40 and 65, copper peptides were found to play a key role in increasing collagen production and stimulating tissue growth.[1]

Some research also shows that copper peptides have antioxidant properties, serving as a cofactor for superoxide dismutase, the body’s strongest antioxidant.[2] If that weren’t enough, the copper peptide also serves as a cofactor for tyrosinase, an enzyme responsible for skin pigmentation. Yes, that means copper peptide also reduces hyperpigmentation.

“According to a study, GHK-Cu has been found to strengthen sagging skin and increase skin elasticity, density and firmness, reduce fine lines and wrinkles, reduce photodamage and hyperpigmentation, and increase keratinocyte proliferation when used in skin care products.”

Copper peptides are also effective for acne. Due to their antibacterial properties, they promote wound healing and collagen synthesis, working to heal breakouts and minimize scarring—just what acne-prone skin needs.

There’s one more fact you should know: Vitamin C, retinol, and AHAs can render copper peptides ineffective, so don’t use them at the same time.

The best copper peptide serums

Without further ado, below are the best copper peptide serums. Pick your favorite and use it every day to support healthy skin aging.

Clinical Skin Polypeptide Firming Serum

When you pay for Clinical Skin Polypeptide Firming Serum, you pay for results. In addition to copper peptides, this serum loads three other peptides, plus four ceramides and cholesterol, all needed for firmer, elastic, and resilient skin. Plus, it packs the active form of vitamin C (ascorbic acid) to induce some more collagen production and defend against free radical damage. The rich yet lightweight formula feels intensely hydrating, leaves skin plump without feeling tacky, and skips fragrances and alcohol. Bonus: once you purchase this serum, you get a massage roller to help you add definition and tighten your skin.

Clinical Skin PolyPeptide Firming Serum

Read review: Clinical Skin PolyPeptide Firming Serum Review

The Ordinary Buffet + Copper Peptides Serum

This serum targets multiple signs of aging and is a great preventative and corrective product all skin types can use. In addition to 1% copper peptides, the formula loads Matrixyl (an anti-aging peptide), a probiotic complex, and a blend of amino acids to repair damaged skin and improve moisture retention. There are also two forms of hyaluronic acid to plump skin and support a vibrant appearance. The formula is lightweight and absorbs fast in the skin, leaving a healthy glow with no residue or tacky feeling. According to most reviewers, The Ordinary Buffet Serum delivers noticeable results in terms of firmness and evenness after four to five weeks.

The Ordinary Copper Peptides Serum

Biossance Squalane + Copper Peptide Rapid Plumping Serum

This one is for those who want a top-rated copper peptide serum that’s also clean, vegan, and sustainable. It has a kick-ass formula powered by a blend of humectants (glycerin, polyglutamic acid, hyaluronic acid, and panthenol) that attract water into the skin, plus squalane to lock moisture. The addition of collagen-supporting copper peptides, along with two other peptides, enhance the production of proteins needed for firm and elastic skin. The result? Bouncy, plump, and firm skin. Better still, everyone can use this serum.

Biossance Squalane + Copper Peptide Rapid Plumping Serum

Perricone MD Cold Plasma Plus Serum Concentrate

Perricone MD products are constantly on the rise, and this copper peptide serum concentrate is no exception. It may look like a moisturizer, but it actually is a lightweight, fast-absorbing serum concentrate that tackles the most visible aging signs. Copper peptide, helped by another three peptides, works hard to spur collagen growth and repair damaged skin, visibly smoothing and softening wrinkles. What’s more, the formula loads a stable, oil-soluble form of vitamin C to brighten dark spots and defend against free radical damage. Most reviewers laud its ability to support a youthful and supple appearance, and we give it extra credit for being formulated sans fragrance or drying alcohol.

Perricone MD Cold Plasma Advanced Serum Concentrate

Alpha-H Vitamin B Serum with Copper Tripeptide

Every morning support your skin with Alpha-H serum that’s fortified with 5% niacinamide, hyaluronic acid, vitamin B, and copper tripeptide. All these tried-and-true actives work to hydrate, even tone, and minimize sun damage. Better still, this serum loads a good amount of antioxidants, including ferulic acid, sage, and gardenia florida extracts, to defend against external foes. The light texture absorbs quickly into the skin, and most people observe their tone improving after the first weeks of daily use.

Serum with Copper Tripeptide

Medik8 Copper PCA Peptides Serum

Who doesn’t want a strong antioxidant defense system to keep photoaging at bay? We all want it, and Medik8 Copper PCA Peptides Serum gives just that and then some. It’s powered by copper peptides to offset free radicals, plus a medley of peptides to induce collagen production and niacinamide to hydrate and brighten. Alongside its age-defying properties, it helps to boost a radiant complexion by adding more antioxidants to the formula — superoxide dismutase, Centella asiatica, and vitamin E. Now you know why this is one of the best copper peptide-infused serums out there.

Medik8 Copper PCA Peptides

Purito DermHA-3 Serum

If loss of firmness and elasticity bothers you, this serum has your back. Not only because it’s infused with copper peptides, but it also contains three molecular sizes of hyaluronic acid for instant and long-term hydration and plumpness. The lightweight yet rich texture sinks into the skin in a flash without ever feeling sticky and leaves your complexion luminous and radiant all day long. In other words, a K-beauty winner.

Purito DermHA-3 Serum

Drunk Elephant Shaba Complex Eye Serum

Drunk Elephant has a great copper peptide serum for the eye area! It’s a milky satiny serum made to help you combat fine lines, dryness, and loss of firmness. It does it all supported by copper peptides, copper lysinate, niacinamide, hyaluronic acid, vitamins C and E, plus black tea ferment, all known to improve aging signs. The formula is clean, lacking fragrances or alcohol, making it a treat for the thin skin around the eyes.

Drunk Elephant Copper Peptide Eye Serum

Neova SmartSkincare Power Defense

Neova SmartSkincare Power Defense packs a Copper Peptide Complex® among the first ingredients, so you can bet it works hard to repair skin and boost collagen. Aside from this, the formula is filled with more peptides to boost resilient skin, sodium hyaluronate to hydrate, vitamin E to soften, and retinyl palmitate to encourage cell renewal. Use it regularly and say hello to firmer, bouncier skin.

Neova SmartSkincare Power Defense

iS CLINICAL Super Serum Advance

This one is a wrinkle-fighter that combines 15% L-ascorbic acid (active form of vitamin C) with copper tripeptide to deliver a high dose of reparative and brightening benefits. The powerful serum also has alpha-arbutin and mushroom extract to correct dark spots, plus Centella asiatica to encourage skin healing. All in all, iS Clinical Super Serum has the perfect combination of ingredients to deliver protection against environmental aggressors and improve the overall skin texture. Aka, if you want to reduce scarring and stretch marks, this serum is for you.

iS CLINICAL Super Serum Advance

Skin Perfection Copper Peptide Serum Booster

If you have a favorite skincare product you wish contained copper peptide, now you can make your wish true. This booster supercharges your serum, moisturizer, or mask by adding extra copper peptides for more benefits. Just pour 1% into your favorite product to boost its anti-aging and antioxidant effects, and you’re ready to go!

Skin Perfection Copper Peptide Serum Booster

The bottom line

Copper peptides are here to stay. While they haven’t yet reached the fame of retinol and vitamin C on the skincare scene, they certainly have something to offer that any skin would love to drink up. Anti-aging, repairing, and protecting, copper peptides check them all, which is why your skin will thank you for slathering one of these serums on it.


  1. Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015.
  2. Travis Badenhorst, Darren Svirskis, Mervyn Merrilees, Liane Bolke and Zimei Wu, School of Pharmacy, Faculty of Medical and Health Sciences, New Zealand, Effects of GHK-Cu on MMP and TIMP Expression, Collagen and Elastin Production, and Facial Wrinkle Parameters, Published date: December 2016.
Who wrote this?
Picture of Ana Vasilescu
Ana Vasilescu
Ana Vasilescu is the founder of Women's Concepts and a certified skincare consultant. She has over five years of experience working in the beauty editorial industry and over a decade as an acne sufferer. With a background in dermatological research, Ana brings a wealth of expertise to a diverse range of topics, from buzzy ingredients to anti-aging and acne advice. She holds a BA in Sociology and Political Sciences. Find her on LinkedIn or Instagram.
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