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How Much Do You Know About The Different Types of Retinoids?

Alesia Kozik
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Expert-approved

This article has been reviewed by Dr. Aznaida T. Pandapatan, a board-certified dermatologist that practices both medical and cosmetic dermatology.

If you want to get the most out of your retinoid product and avoid potential irritation, understanding the different types of retinoids and which ones work best for your skin is a must. These vitamin A derivatives are potent actives, so they are very effective in targeting a wide array of skincare concerns. However, this also makes them not the easiest ingredients to play with, and using retinoids wrongly is definitely something your skin won’t like. Besides, there are quite a few forms of retinoids that address different concerns. Hence, assessing what type of retinoid you need increases the chances that your product will truly deliver.

What are retinoids?

Retinoids are vitamin A derivatives often used to treat acne and photoaging thanks to their ability to regulate cell growth, promote collagen production, accelerate wound healing, reduce wrinkles, and improve skin texture.[1][2] Studies also point out that retinoids have antibacterial, anti-inflammatory, and antioxidant activities and are great brightening agents effective for skin discoloration.[3] Retinol, retinyl palmitate, and tretinoin are all types of retinoids, but they are not all equal in strength and tolerance rate.

While retinoids naturally come from animal sources, those found in skincare formulations are mostly synthetically made. 

Prescription vs. over-the-counter retinoids

There are prescripted retinoids that include the strongest forms (tretinoin, tazarotene, isotretinoin) and are used as a generic medication for moderate and severe skin conditions. On the other hand, skincare products contain over-the-counter retinoids (retinol, retinaldehyde, and retinyl esters) that are gentler and work great for preventing and correcting mild conditions.

How retinoids work

Retinoids work by encouraging cell turnover and inducing collagen production. However, for retinoids to affect your skin cells and provide these benefits, they must first be converted by special enzymes into the active form of vitamin A (retinoic acid). 

Each type of retinoid has to go through one, two, or three conversion steps to become retinoic acid, and the potency of a retinoid is highly affected by the number of conversions it has to go through. Retinoids with the closest proximity to retinoic acid are the strongest, while those with three conversion steps apart provide slower effects (but are also the gentlest).

Tretinoin is the most potent form of retinoids because it doesn’t need to undergo any conversion since it already is the active form of vitamin A. Retinaldehyde and retinol, on the other hand, must be turned by enzymes into usable retinoic acid, so they are milder.

The different types of retinoids

Different types of retinoids are used in skincare, classified according to their strength, the risk of irritation, and what skin conditions they target. 

Tretinoin

Tretinoin, known as Retin-A, is the topical form of pure retinoic acid available only as a prescribed treatment. Since it’s already active, tretinoin does not need to be converted by the skin enzymes, so it’s one of the most potent types of retinoids — 20 times more potent than retinol.[1] It’s usually used in concentrations of 0.025% to 1% as a topical solution to treat severe acne as well as reduce signs of photoaged skin, including wrinkles and dark spots. As the strongest form of retinoid, tretinoin is also the most irritating, so you should use a regenerative moisturizer after tretinoin to increase your skin’s tolerance. Your dermatologist should also align you with everything you need to know to avoid sensitivities when prescribing tretinoin.

Isotretinoin 

Often known as Accutane, isotretinoin is the oral form of pure retinoic acid and the most effective type of retinoid for severe acne. It turns out it’s the only treatment that impacts all of the major causing factors of acne, affecting sebum production, inflammations, and bacteria.[4] According to studies, in low dosages (0.5–1.0 mg), isotretinoin can clear 90% of acne, and the results usually take 16 to 30 weeks to appear. P.S: Isotretinoin carries no anti-aging effects when taken orally.

Tazarotene 

Tazarotene, brand name Tazorac, is a third-generation retinoid and the first topical retinoid developed for the treatment of psoriasis — a condition that causes itchy, dry patches.[5] Tazarotene is also approved by the U.S. Food and Drug Administration (FDA) for acne treatment (only in 0.1% strength) and proved effective for photoaged skin.[6][7] Unlike other retinoids, tazarotene doesn’t convert to retinoic acid once it enters the skin but to its biologically active form of tazarotenic acid.

Adapalene 

Adapalene is a synthetic retinoid derived from naphthoic acid that’s available in both over-the-counter and prescription forms.[1] In fact, it’s the first prescribed retinoid made available over-the-counter since it’s less irritating than tretinoin. Adapalene also does not need to be converted to retinoic acid before it becomes active, so it’s very effective.

Retinaldehyde 

Among the different types of retinoids, retinaldehyde is the most potent OTC form since it requires only one conversion to get into the active form of vitamin A. According to several studies, it offers similar benefits to pure retinoic acid for reducing the signs of photoaging, and it’s also effective for breakouts, skin discoloration, and uneven texture.[1][3] However, compared to retinoic acid or tretinoin, retinaldehyde acts more gently on the skin and is less likely to irritate. Plus, it’s easily accessible since you can find it in all sorts of products, including creams and serums.

Retinol 

Retinol is the most popular form of retinoids used in skincare and one of the best researched ones for sure. Yet, the thing with retinol is that it’s significantly less potent than other types of retinoids, more precisely 20 times less potent than tretinoin.[1] This is because retinol needs to be converted twice — once to retinaldehyde and then to retinoic acid — to become active and provide benefits. The worrying part is that this conversion process is usually slow, resulting in only 5% of retinol being converted to retinoic acid.[8] Regardless, there’s a lot of scientific evidence that proves retinol is effective for wrinkles, acne, dark spots, and lack of firmness, despite its slow conversion rate.

Related: 9 Best Retinol Creams for Beginners To Start Your Retinoid Journey

Retinyl esters

Retinyl esters are the most abundant retinoids present in the body, resulting from binding retinol molecules to fatty acids. The most common retinyl esters used in skincare include retinyl propionate, which is formed by binding retinol with propionic acid, and retinyl palmitate, which results from retinol and palmitic acid. Retinyl esters are usually much gentler and more stable than retinol but also less effective. They’re best suited for people who can’t tolerate other forms of retinoids or have reactive skin.

What to consider when using retinoids

  1. Whenever you add a new retinoid to your skincare routine, it’s best to perform a patch test to see how your skin reacts to the product.
  2. Mild tingling and redness are expected after the first use of retinoids. However, if your skin still reacts to retinoids even after the accommodation period, lower the concentration or discontinue that specific product and opt for gentler forms of retinoids.
  3. Your skin may have difficulty tolerating high concentrations of retinoids at first. So start slowly and increase the frequency and concentration as your skin builds tolerance.
  4. Use retinoids at night since they work better when your skin is in its reparative mode (while you sleep). Besides, retinoids can make your skin photosensitive, so avoid applying them during the day when you often get exposed to the sun. For the same reason, you should always use SPF during the day, especially when following a retinoid treatment.
  5. Retinoids should be avoided during pregnancy.
  6. Since retinoids can temporarily weaken the skin’s barrier, it’s best to apply a repairing moisturizer to speed up the recovery. The moisturizer should contain ingredients like ceramidescholesterol, and fatty acids to reinforce the protective barrier.
  7. Avoid using two retinoids products at the same time or using retinoids with exfoliants like glycolic acid, as you risk compromising your skin’s barrier.
  8. Retinoids degrade quickly when exposed to air, heat, and light, which makes them lose potency. To ensure you use effective products, store your retinoids in a cool, dry place and use packaging that doesn’t let light in.
References

Women’s Concepts uses reliable sources, including dermatologists’ insights, clinical trials, and scientific journals, to find accurate information and support all the facts shared in our articles. All statements and claims have clear and legit references. Read our editorial policy to learn more about our sources of information, our process of researching and fact-checking the content, and how our team strives to keep all articles updated, completed, and trustworthy.

  1. Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/
  2. Leyden J, Stein-Gold L, Weiss J. Why Topical Retinoids Are Mainstay of Therapy for Acne. Dermatol Ther (Heidelb). 2017 Sep, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574737/
  3. Kajal Babamiri, MD, Reza Nassab, MBChB, MBA, MRCSEd, MRCSEng, Cosmeceuticals: The Evidence Behind the Retinoids, Aesthetic Surgery Journal, Volume 30, Issue 1, January 2010, Pages 74–77, https://doi.org/10.1177/1090820X09360704
  4. Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009 May, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835909/
  5. Chandraratna RA. Tazarotene: the first receptor-selective topical retinoid for the treatment of psoriasis. J Am Acad Dermatol. 1997
  6. Gregoriou S, Kritsotaki E, Katoulis A, Rigopoulos D. Use of tazarotene foam for the treatment of acne vulgaris. Clin Cosmet Investig Dermatol. 2014 May 27, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043801/
  7. Lowe N, Gifford M, Tanghetti E, Poulin Y, Goldman M, Tse Y, Yamauchi P, Rosenzweig H, Kang S. Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized, parallel-group study. J Cosmet Laser Ther. 2004 Jun, https://pubmed.ncbi.nlm.nih.gov/15203997/
  8. Kedishvili NY. Retinoic Acid Synthesis and Degradation. Subcell Biochem. 2016, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551983/
Who wrote this?
Ana Vasilescu
Ana Vasilescu
Ana is a sociologist and feminist with a shared passion for literature, psychology, and skincare, the combo that made her determined to start Women's Concepts. With over five years of experience in dermatological research, she has now become a certified skincare consultant keen to convince others of the importance of a diligent routine. Her close relationships with dermatologists around the globe, along with years of researching, analyzing studies, and hand-testing products on a daily basis, made Ana one of the best persons you can get advice from.
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