10 Best Matrixyl Serums to Arrest Aging Signs and Enhance Skin Firmness

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Do your current skin concerns revolve around loss of firmness and wrinkles? Or perhaps you’re hunting for a new product to prevent their apparition (which is a smart call, btw)? Well, adding one of the best Matrixyl serums into your skincare routine could be a game-changing decision that’ll get you bouncy-bouncy skin.

What is Matrixyl?

If you’re not familiar with Matrixyl, it’s basically an A-class peptide (palmitoyl pentapeptide-4) with serious anti-aging benefits. It’s the kind that sends signals to every cell to repair and build proteins, supporting all the skin’s structural components, including collagen, elastin, and hyaluronic acid. And the juicy part: it’s very stable when used in most skincare formulations and can penetrate deep into the skin to act on collagen-producing cells. Thus, diligently using a Matrixyl product over time can actually help diminish fine lines and wrinkles look, smooth texture, and boost hydration — it’s been proven in a bunch of clinical studies already.

The best Matrixyl serums

With this in mind, we’ve pulled out the best Matrixyl serums you can use to arrest fine lines and wrinkles and maintain your skin firm and elastic. In addition to peptides, they’re chocked full of other potent anti-agers and nourishing actives, so you only get the best of the best.

Just for the record, Matrixyl 3000 (palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7) and Matrixyl Synthe’6 (palmitoyl tripeptide-38) are the latter generations of Matrixyl.

The best Matrixyl serums

Scroll on and pick your favorite:


Clinical Skin PolyPeptide Firming Serum
1

Clinical Skin PolyPeptide Firming Serum

Believe me when I say this firming serum is worth saving for — I’m currently using it, and it turned me into a forever fan. The formula loads a heavy dose of anti-aging peptides, including copper peptide, Argireline, and Matrixyl, which have been clinically proven to induce collagen production and enhance firmness with long use. Then, it packs a cocktail of ceramides and fatty acids to reinforce the protective barrier, followed by hyaluronic acid for an intense shot of hydration. And finally, vitamin C and glutathione are added to brighten and enhance radiance. It’s a multi-tasking serum that does pretty much everything, from firming to moisturizing to brightening to protecting to repairing.

Read review:  Clinical Skin PolyPeptide Firming Serum Review 


The Ordinary Matrixyl* 10% + HA
2

The Ordinary Matrixyl 10% + HA

If you’re on a budget, The Ordinary has you covered with an affordable Matrixyl serum that delivers what it promises: firmer and bouncier skin. It touts the two next generations of Matrixyl, 3000 and Synthe’6, coupled with moisturizing glycerin and hyaluronic acid in a pH-balanced formula that is both gentle and effective. It’s alcohol- and fragrance-free and can be used twice daily — by all skin types — to minimize the appearance of fine lines and wrinkles.


Le Mieux TGF-B Booster
3

Le Mieux TGF-B Booster

Hands down, Le Mieux TGF-B Booster is one of the best Matrixyl serums for normal, dry, and sensitive skin. Although not as popular as the others, it excels with a high-performance formula that uses an innovative system to deliver the actives in-depth, where they can trigger transformative changes. Long story short, the serum is made in a hyaluronic acid base, which tells enough about its moisture-retaining powers, and it’s supercharged with the best-in-class peptides (polypeptides, Matrixyl 3000, and epidermal growth factors) to put collagen production on steroids.


Filorga Laboratories NCTF-Intensive Supreme Regenerating Serum
4

Filorga Laboratories NCTF-Intensive Supreme Regenerating Serum

Filorga Laboratories NCTF-Intensive is where Matrixyl meets retinol and vitamin C. Honestly, there’s not much this trio can’t do, being a dream for anyone as it addresses everything from loss of elasticity to fine lines, dark spots, and uneven texture. Besides, the formula loads a bunch of hydrators, brighteners, and replenishers, so your skin gets the best of all worlds. The dispensing system is practical, using a pump that prevents product waste and contaminators from getting into the formula — more bonus points for the lightweight texture that allows an effortless and mess-free application. Warning: this serum contains a meaningful amount of fragrances.


Drunk Elephant Protini Powerpeptide Resurf Serum
5

Drunk Elephant Protini Powerpeptide Resurf Serum

No woman (or man) can go wrong with Drunk Elephant Protini Powerpeptide Resurf Serum. It’s literally the holy grail of peptide serums, combining 10% lactic acid (a mild exfoliant) with no less than 11 signaling peptides — among which Matrixyl 3000 and Matrixyl Synthe’6 — to trigger cell renewal and resurface the skin. In turn, this contributes to a smoother and even complexion with less noticeable blemishes, scars, and fine lines in the long run. Shake it and slather it all over your face AM and PM to enjoy the goodness of this top-performing Matrixyl serum.


Purito Centella Unscented Serum
6

Purito Centella Unscented Serum

If you have sensitized skin, aka easily irritated and reactive, this is the best Matrixyl serum for you. It packs a generous amount of niacinamide, ceramides, and sodium hyaluronate, along with the two main compounds of Centella asiatica (asiaticoside and madecassic acid) to nourish the skin’s barrier and deliver an energizing burst of moisture. The addition of Matrixyl 3000 and two other peptides further supports recovery while working hard to delay the apparition of wrinkles. Things get even better: the lightweight texture absorbs instantly and doesn’t leave skin greasy or sticky but soft, hydrated, and revitalized.


Peter Thomas Roth Peptide Serum
7

Peter Thomas Roth Peptide 21® Wrinkle Resist Serum

This wrinkle-fighting serum is one of Peter Thomas Roth’s best sellers and a favorite for all skin types with its impressive concentration of 73% peptides and neuropeptides. The addition of retinol esters and vitamin C makes your complexion look and feel juicy (and radiant as well), while glycerin, squalane, and sodium hyaluronate provide long-lasting moisture for skin that’s supple and dangerously vibrant. It absorbs quickly, doesn’t feel heavy (just a bit sticky), and leaves a healthy, glowy finish that you’ll be instantly addicted to.


The Inkey List Collagen Peptide Serum
8

The Inkey List Collagen Peptide Serum

Another great Matrixyl serum that won’t break the bank comes from The Inkey List. At just $12, you get a formula spiked with Matrixyl 3000 and another dual peptide complex that works at a cellular level to increase collagen, diminish fine lines and wrinkles appearance, and retexturize the skin. There’s also glycerin and hyaluronic acid for extra hydrating benefits, so your complexion is left moist and firm.


Timeless Skin Care Matrixyl Synthe’6 Serum
9

Timeless Matrixyl Synthe’6 Serum

If you fancy minimalistic formulas, Timeless Matrixyl Synthe’6 Serum is your best bet. It’s made with only seven ingredients, including Matrixyl Synthe’6, aloe vera, glycerin, and hyaluronic acid, helping improve the skin’s appearance on all fronts — minimizing aging signs as it smooths and hydrates. This Matrixyl serum is perfect for dry, sensitive, and mature complexions, but anyone can use it, really. Apply it twice daily, in your morning and nighttime routine, for the best results.


Cos De Baha Peptide Complex Facial Serum with Matrixyl 3000
10

Cos De Baha Peptide Serum with Matrixyl 3000

This serum is coveted by those in the know for its restorative and firming effects. It hasn’t raked in thousands of reviews only for its wallet-friendly price but also for the potent formula infused with niacinamide, Matrixyl 3000, Argireline, and sodium hyaluronate that turn back time on aging signs while hydrating and revitalizing the skin. Have I mentioned it’s made with 79% organic ingredients? Grab it while you can, as it sells like hotcakes.


Who wrote this?
Ana Vasilescu
Ana Vasilescu
Ana is a sociologist and feminist with a shared passion for literature, psychology, and skincare, the combo that made her determined to start Women's Concepts. With over five years of experience in dermatological research, she has now become a certified skincare consultant keen to convince others of the importance of a diligent routine. Her close relationships with dermatologists around the globe, along with years of researching, analyzing studies, and hand-testing products on a daily basis, made Ana one of the best persons you can get advice from.
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